Table 3.

ITP-specific bleeding measurement tools used in prospective studies (n = 10)

Bleeding tool	Experience (Studies (patients, n))	Population	Description	Measurement properties*
Buchanan [13]	11 (480)	Pediatric	Grades (none, minor, mild, moderate, severe) for three anatomical sites, and overall	Good reliability and validity
Mazzucconi [37]	4 (201)	Adult	Severity grades 0–4, blood loss with or without sequelae	Not reported
Page [24]	4 (187)	Pediatric and adult	Ordinal scale from 0 (no bleeding) to 2 (more marked bleeding) at 11 anatomical sites, no overall score	Good reliability and validity
Buchanan [35]	2 (143)	Pediatric	Ordinal bleeding score 0 (definitely no new bleeding) to 4 (bleeding with a drop in hemoglobin> 1 g dL−1)	Not reported
Godeau [36]	1 (122)	Adult	Severity scores at seven anatomical sites plus age and overall	Not reported
Khellaf [23]	2 (120)	Adult	Severity scores for six anatomical sites and age, and overall	Not reported
Zhou [38]	1 (86)	Pediatric and adult	Ordinal scale from 1 to 4	Not reported
Dutch national pediatric ITP protocol [39]	1 (60)	Pediatric	Ordinal bleeding score 0 (none) to 4 (life threatening bleeding)	Not reported
Blanchette [34]	1 (53)	Pediatric	Bleeding grade: moderate or severe	Not reported
SMOG score [10]	1 (50)	Adult	Each of three anatomical sites (skin, mucosa, body organ) are graded from 0 to 4 based on explicit descriptions	Not reported

^*Good reliability and validity were determined based on published criteria [12] by an expert in evaluation. For further details, see Table S3.