Figure 1.

Chromosomal location and expression. A, Chromosomal distribution of differentially methylated probes in abused suicide completers (SAs). The first row represents the chromosomal location of probes with increased methylation (hypermethylated) in the SAs and the second row indicates the chromosomal location of probes with decreased methylation (hypomethylated) in the SAs. B, Inverse correlation between whole-genome expression and promoter methylation differences between SAs and controls. The mean promoter methylation differences (Meth) and gene expression (Expr) differences show that differential methylation is inversely correlated with differential gene expression across the genome (Pearson r= −0.19, P≤4.0E⁻⁶). Data were obtained by summarizing promoter methylation and gene expression differences across regions of 1 megabase throughout the whole genome.