Table 1.
Patient demographics
| n = 46 patients | n | % |
|---|---|---|
| Age at first diagnosis (years; median, range) | 35 (17–54) | |
| Sex (female:male) | 25:21 | 54.3:45.7 |
| IDH1 mutation | 38 | 82.6 |
| Follow-up (months; median, range) | 69 (17.5–164.6) | |
| OS (months; median, range) | 119.8 (17.5–164.6) | |
| PFS (months; median, range) | 45.1 (4.7–164.6) | |
| MPFS (months; median, range) | 81.4 (4.7–164.6) | |
| TTR (months; median, range) | 40.9 (4.5–164.6) | |
| Progression | 26 | 56.5 |
| Malignant progression | 19 | 41.3 |
| Death | 11 | 23.9 |
| Seizure as first diagnosis | 30 | 65.2 |
| Time from radiographic diagnosis to surgery (months; median, range) | 0 (0–91) | |
| KPS pre-op (median, range) | 100 (80–100) | |
| KPS post-op (median, range) | 100 (70–100) | |
| New permanent neurologic deficits | ||
| None | 43 | 93.5 |
| Yes | 3 | 6.5 |
| Tumor eloquence | 6 | 13 |
| Tumor side (left:right) | 20:26 | 43.5:56.5 |
| Tumor localization (lobe) | ||
| Frontal | 23 | 50 |
| Temporal | 18 | 39.1 |
| Others | 5 | 10.9 |
| Contrast enhancement pre-op | 14 | 30.4 |
| dT2T1 (cm3, median, range) | 3.41 (−43.02 to 64.52) | |
| Upfront adjuvant treatment | 7 | 15.2 |
| Chemotherapy | 2 | |
| Radiotherapy | 3 | |
| Combined radio-/chemotherapy | 2 | |
| Complete resection planned | 27 | 58.7 |
| iMRI employed | 33 | 71.7 |
| Continued resection after iMRI | 27 | (81.8) |
| Vol. pre-op (cm3; median, range) | 44.23 (0.78–193.04) | |
| Vol. iMRI (cm3; median, range) | 4.95 (0–143.94) | |
| EOR iMRI (%; median, range) | 69.5 (13.3–100) | |
| Vol. epMRI (cm3; median, range) | 5.32 (0–113.9) | |
| EOR epMRI (%; median, range) | 69.6 (10.9–100) | |
| Vol. follow-up MRI (cm3; median, range) | 4.09 (0–167.98) | |
| EOR follow-up MRI (%; median, range) | 90.4 (17.5–100) | |
OS overall survival, PFS progression-free survival, MPFS malignant progression-free survival, TTR time to re-intervention, KPS Karnofsky Performance Score, Vol (tumor) volume, iMRI intraoperative MRI, epMRI early postoperative MRI, EOR extent of resection, dT2T1 volumetric difference of signal abnormality between preoperative T2-FLAIR sequences and native T1 sequences