Table 3.

Univariate analysis of overall survival

	Full study sample (n = 46)			IDH1 mt. (n = 38)			EOR ≥40 % (n = 39)			EOR ≥40 %/IDH1 mt. (n = 32)
	HR	95 % CI	p value	HR	95 % CI	p value	HR	95 % CI	p value	HR	95 % CI	p value
IDH1 mutation (y/n)	0.11	0.03	0.00029		N.A.		0.21	0.03	0.058		N.A.
		0.46						1.26
Vol preoperative (cm3)	1.0073	0.9958	0.203	1.0151	0.9997	0.032	1.0265	1.0038	0.005	1.0727	0.9800	0.0005
		1.0189			1.0308			1.0497			1.1742
Vol epMRI (cm3)	1.0136	0.9974	0.078	1.0201	0.9981	0.035	1.0311	0.9711	0.296	1.0351	0.9387	0.458
		1.030			1.0425			1.0948			1.1415
Vol follow-up MRI (cm3)	1.0059	0.9951	0.278	1.0085	0.9966	0.148	1.0776	1.0116	0.007	1.0925	1.0042	0.011
		1.0168			1.0206			1.1480			1.1886
EOR epMRI (%)	0.138	0.009	0.141	0.062	0.001	0.114	0.448	0.010	0.674	1.070	0.001	0.985
		2.151			2.711			19.384			1333.103
EOR follow-up MRI (%)	0.279	0.058	0.100	0.274	0.042	0.158	0.350	0.003	0.662	0.509	0.001	0.830
		1.342			1.771			39.699			242.487
dT2T1 preoperative (cm3)	0.9995	0.9635	0.980	0.9954	0.9535	0.835	1.2170	1.0321	0.00009	1.3150	0.9441	0.00005
		1.0370			1.0392			1.4349			1.8316
Adjuvant therapy at first diagnosis (y/n)	6.25	1.79	0.0010	12.25	2.22	0.0003	4.87	0.43	0.159	12.55	0.78	0.022

p values were calculated using a log-rank test. Variables were only regarded significant if 1 was not included in 95 % confidence intervals. Significant values are presented in bold face. Volumetric measures were analyzed as un-dichotomized, continuous variables

EOR extent of resection, dT2T1 difference in tumor volume expansion on preoperative T2 and T1 sequences