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. 2016 Jul 22;420:129–140. doi: 10.1007/s11010-016-2776-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — The results of differential gene expression analysis. a Heat map showing the clustering of samples by genes that significantly increased (red font) or decreased (green font) following TRPC1 silencing. 40 genes were up-regulated and 31 genes down-regulated significantly in TRPC1-silenced (siTRPC1) cells compared to control cells. Red and green colours represent relative high and low log2 gene expression values, respectively. b Molecular functions of differently expressed genes. c Correlation of TRPC1 expression data obtained from microarray and quantitative real-time RT-PCR (siTRPC1 = blue, Pearson correlation, n = 10). d Effects of silencing on TRPC1 protein levels measured by Western blot following 72-h vector incubation (n = 4). (Color figure online)