Table 1.
The alterations in gene expression levels in TRPC1-silenced Huh7 cells
| Gene symbol | Description | Log2FC | FDR | P value | |
|---|---|---|---|---|---|
| 1 | MARK2 | MAP/microtubule affinity-regulating kinase 2 | 1.02 | 0.00050 | 0.000000042 |
| 2 | ELAVL3 | Embryonic lethal, abnormal vision, drosophila-like 3 | 0.94 | 0.00020 | 0.000000042 |
| 3 | MDM4 | Mdm4 p53 binding protein homologue (mouse) | 0.89 | 0.00030 | 0.000000084 |
| 4 | CXorf40A | Chromosome X open reading frame 40A | 0.82 | 0.0014 | 0.00000046 |
| 5 | SNORD13 | Small nucleolar RNA, C/D box 13 | 0.81 | 0.0022 | 0.00000092 |
| 6 | IPO7 | Importin 7 | 0.82 | 0.0020 | 0.0000011 |
| 7 | IPO7P2 | N/A (pseudogene) | 0.82 | 0.0020 | 0.0000011 |
| 8 | CILP | Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.77 | 0.0030 | 0.0000020 |
| 9 | PTHLH | Parathyroid hormone-like hormone | 0.75 | 0.0039 | 0.0000029 |
| 10 | ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.77 | 0.0039 | 0.0000033 |
| 11 | HNRNPKP4 | N/A (pseudogene) | 0.76 | 0.0042 | 0.0000039 |
| 12 | FXYD5 | FXYD domain containing ion transport regulator 5 | 0.77 | 0.0041 | 0.0000041 |
| 13 | TAOK1 | TAO kinase 1 | 0.72 | 0.0040 | 0.0000044 |
| 14 | KLHL28 | Kelch-like 28 (drosophila) | 0.73 | 0.0044 | 0.0000051 |
| 15 | HNRNPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.73 | 0.0042 | 0.0000053 |
| 16 | SFXN1 | Sideroflexin 1 | 0.71 | 0.0044 | 0.0000059 |
| 17 | TEX28 | Testis expressed 28 | 0.73 | 0.0046 | 0.0000066 |
| 18 | ARL2 | ADP-ribosylation factor-like 2 | 0.71 | 0.0045 | 0.0000068 |
| 19 | MIR4444-2 | RNA gene (MicroRNA 4444-2) | 0.70 | 0.0066 | 0.000010 |
| 20 | C17orf67 | Chromosome 17 open reading frame 67 | 0.64 | 0.0082 | 0.000014 |
| 21 | RN7SL657P | N/A (pseudogene) | 0.65 | 0.013 | 0.000023 |
| 22 | ITLN2 | Intelectin 2 | 0.64 | 0.017 | 0.000032 |
| 23 | CXorf40B | Chromosome X open reading frame 40B | 0.64 | 0.019 | 0.000036 |
| 24 | SPAG8 | Sperm-associated antigen 8 | 0.60 | 0.020 | 0.000039 |
| 25 | SMCP | Sperm mitochondria-associated cysteine-rich protein | 0.58 | 0.019 | 0.000040 |
| 26 | SLC7A5P1 | Solute carrier family 7, member 5 pseudogene 1 | 0.64 | 0.019 | 0.000041 |
| 27 | COL4A2 | Collagen, type IV, alpha 2 | 0.64 | 0.021 | 0.000047 |
| 28 | DUSP8 | Dual specificity phosphatase 8 | 0.61 | 0.028 | 0.000066 |
| 29 | PRPS2 | Phosphoribosyl pyrophosphate synthetase 2 | 0.58 | 0.030 | 0.000072 |
| 30 | CD1C | CD1c molecule | 0.55 | 0.032 | 0.000080 |
| 31 | TBX21 | T-box 21 | 0.60 | 0.032 | 0.000083 |
| 32 | INPP5 K | Inositol polyphosphate-5-phosphatase K | 0.60 | 0.032 | 0.000085 |
| 33 | SUDS3 | Suppressor of defective silencing 3 homologue (Saccharomyces cerevisiae) | 0.59 | 0.037 | 0.00010 |
| 34 | IPCEF1 | Interaction protein for cytohesin exchange factors 1 | 0.57 | 0.046 | 0.00013 |
| 35 | CLIC5 | Chloride intracellular channel 5 | 0.56 | 0.048 | 0.00014 |
| 36 | SOSTDC1 | Sclerostin domain containing 1 | 0.56 | 0.048 | 0.00014 |
| 37 | DTD2 | d-tyrosyl-TRNA deacylase 2 (putative) | 0.58 | 0.047 | 0.00015 |
| 38 | MAGEB3 | Melanoma antigen family B, 3 | 0.47 | 0.047 | 0.00015 |
| 39 | LGALS9 | Lectin, galactoside-binding, soluble, 9 | 0.52 | 0.049 | 0.00016 |
| 40 | SLC7A5P2 | SLC7A5 pseudogene | 0.56 | 0.050 | 0.00017 |
| 41 | ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif, 8 | −0.97 | 0.0010 | 0.000000084 |
| 42 | HSPA6 | Heat shock 70 kDa protein 7 (HSP70B) | −0.82 | 0.0025 | 0.00000042 |
| 43 | CES5A | Carboxylesterase 5A | −0.77 | 0.0027 | 0.00000067 |
| 44 | HERC2P2 | N/A (pseudogene) | −0.76 | 0.0038 | 0.0000014 |
| 45 | HERC2P9 | N/A (pseudogene) | −0.76 | 0.0038 | 0.0000014 |
| 46 | HSPA1A | Heat shock 70 kDa protein 1A | −0.74 | 0.0045 | 0.0000023 |
| 47 | UAP1L1 | UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 | −0.74 | 0.0044 | 0.0000026 |
| 48 | SCNN1D | Sodium channel, non-voltage-gated 1, delta | −0.73 | 0.0043 | 0.0000029 |
| 49 | ANKRD1 | Ankyrin repeat domain 1 (cardiac muscle) | −0.73 | 0.0040 | 0.0000030 |
| 50 | AMY2B | Amylase, alpha 2B (pancreatic) | −0.64 | 0.012 | 0.0000097 |
| 51 | AHDC1 | AT hook, DNA binding motif, containing 1 | −0.67 | 0.015 | 0.000014 |
| 52 | STS | Steroid sulfatase (microsomal), isozyme S | −0.65 | 0.017 | 0.000017 |
| 53 | C16orf71 | Chromosome 16 open reading frame 71 | −0.63 | 0.020 | 0.000022 |
| 54 | ZNF354A | Zinc finger protein 354A | −0.62 | 0.025 | 0.000029 |
| 55 | CCDC93 | Coiled-coil domain containing 93 | −0.61 | 0.029 | 0.000036 |
| 56 | TRAF1 | TNF receptor-associated factor 1 | −0.59 | 0.031 | 0.000042 |
| 57 | CEP120 | Centrosomal protein 120 kDa | −0.62 | 0.030 | 0.000042 |
| 58 | FAM234A | Family with sequence similarity 234 member A | −0.61 | 0.032 | 0.000049 |
| 59 | GALNT2 | Polypeptide N-Acetylgalactosaminyltransferase 2 | −0.57 | 0.041 | 0.000065 |
| 60 | SEC24D | SEC24 family, member D (S. cerevisiae) | −0.58 | 0.039 | 0.000066 |
| 61 | SGTB | Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | −0.51 | 0.046 | 0.000081 |
| 62 | VN1R2 | Vomeronasal 1 receptor 2 | −0.61 | 0.044 | 0.000081 |
| 63 | LRRN2 | Leucine rich repeat neuronal 2 | −0.58 | 0.043 | 0.000083 |
| 64 | PSMD4 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | −0.38 | 0.043 | 0.000086 |
| 65 | FAM81A | Family with sequence similarity 81, member A | −0.58 | 0.045 | 0.000094 |
| 66 | SNX10 | Sorting nexin 10 | −0.55 | 0.044 | 0.000095 |
| 67 | TTTY14 | Testis-specific transcript, Y-linked 14 | −0.55 | 0.043 | 0.000097 |
| 68 | HKDC1 | Hexokinase domain containing 1 | −0.56 | 0.043 | 0.00010 |
| 69 | SLC1A7 | Solute carrier family 1 (glutamate transporter), member 7 | −0.59 | 0.044 | 0.00011 |
| 70 | C4orf3 | Chromosome 4 open reading frame 3 | −0.57 | 0.049 | 0.00012 |
| 71 | CPSF7 | Cleavage and polyadenylation specific factor 7, 59 kDa | −0.56 | 0.048 | 0.00012 |