Figure 1. Summary statistics for mutation discovery in the Harwell ageing Screen.

(a) The distribution of the numbers of affected mice observed for each mutation within the G₃ pedigrees. For lines with low numbers of affected mice, putative mutations were confirmed by inheritance testing and/or cloning of the underlying mutation. (b) The distribution of the number of mutations identified per pedigree from a total of 105 mutant lines identified from a total of 157 pedigrees. (c) The distribution of mutation discovery over time. The time point of the initial identification of an individual phenotype is represented here for a total of 105 mutant lines identified in the screen to date. Where mutants were outliers in more than one phenotypic test the time point of the first test to reveal an abnormality is shown.