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. 2016 Aug 18;7:12444. doi: 10.1038/ncomms12444

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Copyright © 2016, The Author(s)

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Minimum auditory detection thresholds (decibel SPL (dB SPL)) were determined using ABR and scored independently by two operators. (a) At 2 months of age, Slc4a10^trmb/trmb (homozygous) mice (n=44) show only a very mild elevation in ABR thresholds in comparison with Slc4a10^+/trmb (heterozygous) (n=54) and Slc4a10^+/+ (wild-type) (n=18) littermates. (b) At 6 months of age, the very mild elevation of ABR thresholds is still observed in Slc4a10^trmb/trmb mice (n=10) compared with Slc4a10^+/trmb (n=21) and Slc4a10^+/+ (n=13) littermates. (c) By 9 months of age, Slc4a10^trmb/trmb mice (n=26) show significantly elevated ABR thresholds (∼20 dB shift) across all frequencies tested compared with Slc4a10^+/trmb (n=25) and Slc4a10^+/+ (n=6) littermates. (d) At 12 months of age, Slc4a10^trmb/trmb mice (n=17) continue to have elevated thresholds compared with the normal hearing Slc4a10^+/trmb (n=13) and Slc4a10^+/+ (n=7) control mice. In addition, the average hearing thresholds of Slc4a10^trmb/trmb mice increase between 9 and 12 months of age. The Slc4a10^+/trmb and Slc4a10^+/+ control mice do not show any auditory decline during the first 12 months of life, nor do they show any significant differences between their auditory thresholds at any frequency or age tested. Black circle/line, Slc4a10^+/+; grey square/line, Slc4a10^+/trmb; red triangle/line, Slc4a10^trmb/trmb. Data shown are mean ±s.e.m. and significance determined using a one-way ANOVA with Tukey's multiple comparisons test comparing Slc4a10^trmb/trmb threshold data with the corresponding Slc4a10^+/+ control data: *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.