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. 2016 Aug 19;7:12470. doi: 10.1038/ncomms12470

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Docking prediction of 19a covalently bound to Cys190 of human PPARγ. The model was created using the protein–ligand docking program GOLD. (b) Measurement of 19a binding to WT, C176A and D174A PPARγ using gel-based competitive assay. The proteins were transiently expressed in 293T cells and the cellular lysates were treated with different concentrations of 19a for 1 h followed by 24c-Cy3 (10 μM). Dose–response curves are shown.