Table 1.

Doses of baclofen or placebo adjusted on daily assessment of the patient’s creatinine clearance

MDRD	D1 Loading dose	D2 and following days until extubation/tracheotomy at D15
Cl ≥90	150 mg	50-50-50
Cl 89–60	100 mg	30-20-50
Cl 30–59	70 mg	20-20-30
Cl <30 or continuous HD	50 mg	20-10-20
IHD	50 mg	50 mg before each session
Cl <15 without HD/IHD	50 mg	No administration

Cl renal clearance, D day, HD haemodialysis, IHD intermittent haemodialysis, MDRD modification of the diet in renal disease