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. 2016 Aug 20;13:45. doi: 10.1186/s12989-016-0156-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic representation of the nanoparticle PBPK model developed in this study for inhalation, with sub-compartments of phagocytizing cells (PCs) in each tissue. Arrows represent the direction of various pathways for the nanoparticles to migrate from one location to another. Nanoparticles may not be endocytosed by PCs nor migrate into the tissue matrix and exist in a “free” state in the tracheobronchial and pulmonary region of the lung