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. 2016 Aug 20;13:45. doi: 10.1186/s12989-016-0156-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Log₁₀ of predicted CeO₂ nanoparticle amount as a function of log₁₀ of measured amount in different organs. R² represents the deviation from the line of unity between the log₁₀ of measured and PBPK model predicted values. With R ² = 1 representing perfect prediction of the measured CeO₂ nanoparticle amount from the PBPK model. GSD² indicates the differences (in factors) between the predicted and measured amounts of individual data points for all organs at all times. a Results for experiment fresh 1. b Results for experiment fresh 2. c Results for experiment aged 1. d Results for experiment aged 2