Table 3.
Relationship between NSAID consumption and breast cancer according to women’s characteristics
| Population | NSAID | Unexposed controls/cases (n) | Exposed controls/Cases (n) | OR (95 % CI) | p |
|---|---|---|---|---|---|
| All women | NSAID (all) | 1170/1111 | 739/625 | 0.76 (0.64–0.89) | 0.001 |
| Aspirin | 1807/1653 | 102/83 | 0.91 (0.64–1.29) | 0.60 | |
| Acetic acid derivatives | 1753/1620 | 156/116 | 0.75 (0.55–1.01) | 0.06 | |
| Propionic acid derivatives | 1350/1232 | 559/504 | 0.82 (0.69–0.98) | 0.03 | |
| cox2 inhibitors | 1891/1731 | 18/5 | 0.28 (0.09–0.88) | 0.03 | |
| NSAID others | 1861/1697 | 48/39 | 1.13 (0.67–1.89) | 0.65 | |
| Premenopausal | NSAID (all) | 361/415 | 267/287 | 0.80 (0.60–1.07) | 0.14 |
| Aspirin | 613/689 | 15/13 | 0.60 (0.25–1.47) | 0.27 | |
| Acetic acid derivatives | 600/664 | 28/38 | 0.75 (0.42–1.36) | 0.35 | |
| Propionic acid derivatives | 392/451 | 236/251 | 0.84 (0.62–1.13) | 0.24 | |
| cox2 inhibitors | 626/701 | 2/1 | - | - | |
| NSAID others | 618/693 | 10/9 | 1.26 (0.41–3.9) | 0.69 | |
| Postmenopausal | NSAID (all) | 804/696 | 462/338 | 0.69 (0.56–0.86) | <0.001 |
| Aspirin | 1180/964 | 86/70 | 0.99 (0.68–1.46) | 0.98 | |
| Acetic acid derivatives | 1142/956 | 124/78 | 0.72 (0.50–1.03) | 0.07 | |
| Propionic acid derivatives | 953/781 | 313/253 | 0.78 (0.62–0.98) | 0.03 | |
| cox2 inhibitors | 1250/1030 | 16/4 | - | - | |
| NSAID others | 1228/1004 | 38/30 | 1.05 (0.58–1.90) | 0.86 | |
| BMI <25 | NSAID (all) | 578/537 | 364/282 | 0.73 (0.57–0.94) | 0.02 |
| Aspirin | 901/794 | 41/25 | 0.74 (0.40–1.35) | 0.32 | |
| Acetic acid derivatives | 883/783 | 59/36 | 0.54 (0.31–0.93) | 0.03 | |
| Propionic acid derivatives | 656/575 | 286/244 | 0.86 (0.66–1.13) | 0.27 | |
| cox2 inhibitors | 932/816 | 10/3 | - | - | |
| NSAID others | 919/806 | 23/13 | 0.98 (0.42–2.31) | 0.97 | |
| BMI >25 | NSAID (all) | 592/574 | 375/343 | 0.76 (0.60–0.95) | 0.02 |
| Aspirin | 906/859 | 61/58 | 1.01 (0.65–1.56) | 0.96 | |
| Acetic acid derivatives | 870/837 | 97/80 | 0.81 (0.56–1.18) | 0.27 | |
| Propionic acid derivatives | 694/657 | 273/260 | 0.78 (0.61–1.00) | 0.05 | |
| cox2 inhibitors | 959/915 | 8/2 | - | - | |
| NSAID others | 942/891 | 25/26 | 1.24 (0.64–2.41) | 0.52 |
OR Odds ratio adjusted for age, recruitment area, education level, tobacco smoking history, BMI family history of breast cancer, number of deliveries, age at first delivery, menarche age, and menopausal status. CI confidence interval