Table 2.
Association between SNPs and ischemic stroke using the additive, genotype, dominant, and the recessive models
| SNP | Model | Allele or geno | case | control | Unadjusted OR (95 % CI) | Unadjusted p-value |
Adjusted OR (95 % CI) |
Adjusted p-value |
|---|---|---|---|---|---|---|---|---|
| rs579459 | Additive | C/T | 363/1455 | 334/1576 | 1.18 (1.00-1.39) | 0.05 | 1.18 (0.97-1.43) | 0.10 |
| Dominant | CC + CT/TT | 326/583 | 300/655 | 1.22 (1.00-1.48) | 0.04 | 1.20 (0.95-1.52) | 0.12 | |
| Recessive | CC/CT + TT | 37/872 | 34/921 | 1.15 (0.71-1.85) | 0.57 | 1.31 (0.74-2.31) | 0.36 | |
| rs651007 | Additive | T/C | 349/1421 | 337/1575 | 1.15 (0.97-1.36) | 0.10 | 1.15 (0.94-1.40) | 0.17 |
| Dominant | TT + CT/CC | 314/571 | 304/652 | 1.18 (0.97-1.43) | 0.09 | 1.16 (0.92-1.46) | 0.22 | |
| Recessive | TT/CT + CC | 35/850 | 33/923 | 1.15 (0.71-1.87) | 0.57 | 1.35 (0.76-2.40) | 0.31 | |
| rs529565 | Additive | C/T | 679/1087 | 709/1201 | 1.06 (0.93-1.21) | 0.41 | 1.06 (0.90-1.24) | 0.48 |
| Dominant | CC + CT/TT | 540/343 | 565/390 | 1.09 (0.90-1.31) | 0.38 | 1.08 (0.86-1.35) | 0.52 | |
| Recessive | CC/CT + TT | 139/744 | 144/811 | 1.05 (0.82-1.36) | 0.69 | 1.08 (0.79-1.47) | 0.62 |
All SNPs were analyzed under additive, genotype, dominant (Dom) and recessive (Rec) models; OR: odds ratio; CI: confidence interval; unadjusted P-value from t-test; adjusted P-value using logistic regression analysis with age, gender, hypertension, diabetes, and dyslipidemia as covariates. Significant P values (p < 0.05) are in bold and p* < 0.017 (Bonferroni multiple correction threshold)