Table 3.
Association between SNPs and LAA using the additive, genotype, dominant, and the recessive models
| SNP | Model | Allele or geno | case | control | Unadjusted OR (95 % CI) | Unadjusted p-value |
Adjusted OR (95 % CI) |
Adjusted p-value |
|---|---|---|---|---|---|---|---|---|
| rs579459 | Additive | C/T | 197/721 | 334/1576 | 1.29 (1.06-1.57) | 0.01 | 1.27 (1.00-1.61) | 0.047 |
| Dominant | CC + CT/TT | 174/285 | 300/655 | 1.33 (1.06-1.68) | 0.015 | 1.28 (0.96-1.70) | 0.09 | |
| Recessive | CC/CT + TT | 23/436 | 34/921 | 1.43 (0.83-2.46) | 0.19 | 1.70 (0.88-3.29) | 0.11 | |
| rs651007 | Additive | T/C | 193/703 | 337/1575 | 1.28 (1.05-1.56) | 0.01 | 1.30 (1.02-1.64) | 0.033 |
| Dominant | TT + CT/CC | 170/278 | 304/652 | 1.31 (1.04-1.66) | 0.02 | 1.29 (0.97-1.71) | 0.08 | |
| Recessive | TT/CT + CC | 23/425 | 33/923 | 1.51 (0.88-2.61) | 0.13 | 1.89 (0.97-3.65) | 0.06 | |
| rs529565 | Additive | C/T | 374/518 | 709/1201 | 1.22 (1.04-1.44) | 0.01 | 1.24 (1.02-1.51) | 0.03 |
| Dominant | CC + CT/TT | 295/151 | 565/390 | 1.35 (1.07-1.71) | 0.01 | 1.39 (1.05-1.84) | 0.02 | |
| Recessive | CC/CT + TT | 79/367 | 144/811 | 1.21 (0.90-1.64) | 0.21 | 1.24 (0.86-1.79) | 0.25 |
All SNPs were analyzed under additive, genotype, dominant (Dom) and recessive (Rec) models; OR: odds ratio; CI: confidence interval; unadjusted P-value from t-test; adjusted P-value using logistic regression analysis with age, gender, hypertension, diabetes, and dyslipidemia as covariates. Significant P values (p < 0.05) are in bold and p* < 0.017 (Bonferroni multiple correction threshold)