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. 2016 Aug 19;13:188. doi: 10.1186/s12974-016-0655-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Histopathological analysis of Streptococcus pneumoniae-infected zebrafish embryos via the caudal vein at 2 days post - fertilization. a, b Caudal vein injection at 2 days post - fertilization (dpf). Sagittal section of the head region showing the bacteria (arrows) in the brain parenchyma at a 12 h post injection (hpi) and at b 24 hpi. c, d Caudal vein-injected zebrafish embryos at 4 dpf. c Sagittal section at 24 hpi showing bacteria (arrows) in the meningeal space and in d the brain parenchyma. Scale bars, 10 μm