Fig. 1.

Hypothermia reduces ischemic infarct volume in MCAO rats. a, An illustration of the experimental schedule. b, Body temperature traces in rats after middle cerebral artery occlusion (MCAO). c, Representative images of 2,3,5-triphenyltetrazolium chloride (TTC) staining results. d, A quantification of infarct volume measured in TTC-stained brain slices of rats treated with MCAO and/or hypothermia. The number of rats in each group was as follows: sham (n = 3), hypothermia (n = 4), MCAO (n = 5), MCAO + hypothermia (n = 4). ### P < 0.001 versus sham alone, ** P < 0.01 comparing MCAO with and without hypothermia, one-way analysis of variance (ANOVA) followed by the Bonferroni post hoc test