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. Author manuscript; available in PMC: 2016 Aug 20.
Published in final edited form as: J Appl Toxicol. 2009 Nov;29(8):703–714. doi: 10.1002/jat.1462

Table 1.

Summary of the reproductive findings for male and female pups born to dams exposed to BBP by gavage from gd 14-gd 21.

Control Group: 17 males: 13 females

  • No findings

Low dose (25 mg/kg/day) 16 males

  • A total of 9 male pups in the three litters had reproductive findings

  • 2 males had decreased AGD on pnd 21

  • 7 males had retained areolae

  • At pnd 26, all AGD values for the pups exposed to BBP were similar to control values

Low dose (25 mg/kg/day) 15 females

  • No significant findings

 High Dose (750 mg/kg/day) 6 males

  • 6 males had retained areolae

  • 3 males had retained nipples

  • 6 males had decreased AGD

  • 6 males were missing part/all of epididymis

  • 6 males were missing seminal vesicles

  • 2 males had missing or abnormal prostate

  • 4 males exhibited missing or abnormal testes

  • 1 male had a cleft phallus

  • 3 males were missing all/part of vas deferens

High Dose (750 mg/kg/day) 9 females

  • No significant findings