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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Inflamm Bowel Dis. 2016 Sep;22(9):2265–2279. doi: 10.1097/MIB.0000000000000858

Figure 2. The Non-Canonical NF-κB Pathway.

Figure 2

NF-κB inducing kinase (NIK) is constantly being translated. However, under normal unstimulated conditions, NIK is ubiquitinated and degraded via the TRAF3/TRAF2/cIAP1/cIAP2 complex. Upon stimulation by TNF family ligands, this complex is degraded via K48 ubiquitination, which allows NIK to interact with and phosphorylate IKKα. IKKα then phosphorylates p100, leading to its cleavage to p52. The processing of p100 allows the RelB/p52 dimer to enter the nucleus and initiate transcription of non-canonical NF-κB associated genes, such as CXCL12 and CXCL13.