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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Hepatol. 2016 May 2;65(3):608–617. doi: 10.1016/j.jhep.2016.04.018

Figure 3. Sinusoidal crosstalk during liver regeneration.

Figure 3

Upon hepatectomy, initial signals (mainly IL-6) from Kupffer cells (KC), macrophages and other non-myeloid cells lead to the first burst of hepatocytes proliferation, which in turn will produce vascular endothelial growth factor (VEGF) to recruit bone marrow-derived sinusoidal progenitor cells (BM SPC) as a key source of hepatocyte growth factor (HGF). Latterly, hepatic stellate cells (HSC) and liver sinusoidal endothelial cells (LSEC) contribute to the regeneration process.