Fig. 6.

Discrimination of significant hepatic fibrosis by let-7s expression levels in extracellular vesicles. (A) Expression levels of the candidate microRNAs in extracellular vesicles (EVs) between chronic hepatitis C patients with or without significant fibrosis (Ishak score 3-6 at initial liver biopsy). Boxes represent the interquartile range of the data. The lines across the boxes and the numbers indicate the median values. The hash marks above and below the boxes indicate the 90th and 10th percentiles for each group, respectively. P-values were calculated by Mann-Whitney U-test. (B) The receiver operating characteristic curve analyses were carried out and the area under the curves (AUC) were calculated to evaluate capabilities of the candidate miRNA levels in EVs for discriminating significant hepatic fibrosis.