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. 2016 May 20;64(3):880–893. doi: 10.1002/hep.28599

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© 2016 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Biliatresone causes epithelial leakiness. Cholangiocyte spheroids were loaded with rhodamine, treated with vehicle (DMSO) or biliatresone for 12 hours, and imaged every 20 minutes. (A) Representative spheroids at 1, 3, 6, and 12 hours. Scale bars: 10 μm. (B) Quantification of rhodamine loss from spheroids over 12 hours (biliatresone, n = 17; DMSO, n = 18) from six independent experiments. The time at which >50% of the luminal signal was lost was scored. Data are presented as the mean ± standard deviation (P < 0.0001).