Table 3.
Summary estimates for the odds ratio (OR) of MTHFR C677T in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric and publication bias p value (Egger Test)
| Genetic Models | Fixed effect OR (95 % CI), p |
Random effect OR (95 % CI), p |
Heterogeneity p value (Q test) | I2 (%) | Publication Bias (p of Egger’s test) |
|---|---|---|---|---|---|
| Allele Contrast (T vs. C) | 1.28 (1.17–1.4), <0.0001 | 1.35 (1.09–1.68), 0.009 | <0.0001 | 85.07 | 0.24 |
| Co-dominant (CT vs. CC) | 1.32 (1.17–1.5), <0.0001 | 1.39 (1.07–1.8), 0.01 | <0.0001 | 72.43 | 0.45 |
| Homozygoote (TT vs. CC) | 1.43 (1.18–1.7), 0.0002 | 1.79 (1.23.2.6), 0.007 | <0.0001 | 77.98 | 0.02 |
| Dominant (TT + CT vs. CC) | 1.32 (1.18–1.47), <0.0001 | 1.44 (1.14–1.82), 0.006 | <0.0001 | 80.8 | 0.16 |
| Recessive (TT vs. CT + CC) | 1.29 (1.08–1.5), 0.004 | 1.61 (1.02–2.56), 0.04 | <0.0001 | 78.1 | 0.06 |