Table 1.
Epidemiological and clinical characteristics of 40 ICU patients with fungemia caused by fluconazole-resistant C. parapsilosis (FRCP) and fluconazole-susceptible Candida species (FSC)
| FRCP (N = 21) | FSCa (N = 19) | P value | |
|---|---|---|---|
| Age (years) - median (range) | 70 (23–91) | 76 (35–90) | 0.311 |
| Gender female - n (%) | 7 (33.3) | 8 (42.1) | 0.567 |
| Time to candidemia – median/range | 22 (0–83) | 25 (7–134) | 0.185 |
| Apache II score – median/range | 14 (3–29) | 16 (3–30) | 0.138 |
| Death up to 30 days after candidemia (%) | 9 (42.9) | 9 (47.4) | 0.78 |
| Comorbidities - n (%) | |||
| Cancer | 5 (23.8) | 2 (10.5) | 0.270 |
| Pulmonary disease | 9 (42.9) | 11 (57.9) | 0.342 |
| Cardiac disease | 6 (28.6) | 3 (15.8) | 0.557 |
| Diabetes mellitusb | 11 (52.4) | 2 (10.5) | 0.013 |
| Renal failure | 4 (19.0) | 3 (15.8) | 1.000 |
| Previous exposure to medical procedures and medicines - n (%) | |||
| Short-term catheter | 21 (100.0) | 17 (89.5) | 0.424 |
| Catheter tip positive | 4 (19.0) | 3 (15.8) | 1.000 |
| Previous hemodialysis | 3 (14.3) | 1 (5.3) | 0.673 |
| Prior surgery | 12 (61.9) | 10 (52.6) | 0.775 |
| Mechanical ventilation | 15 (71.4) | 14 (73.7) | 0.873 |
| Parenteral nutrition | 7 (33.3) | 1 (5.3) | 0.059 |
| Previous Hospitalization | 4 (19) | 8 (42.1) | 0.112 |
| Antibiotics | 10 (47.6) | 8 (42.1) | 0.726 |
| Steroids | 8 (38.1) | 7 (36.8) | 0.942 |
| Any antifungal drug | 7 (33.3) | 3 (15.8) | 0.361 |
| Fluconazole | 4 (19.0) | 3 (15.8) | 1.000 |
aall Candida strains considered susceptible to fluconazole by the Vitek 2 system. bvariable identified as independent factor associated with infection by FRCP