TABLE 4.

Summary of metabolic tumor volume (MTV) studies in head and neck patients treated with radiotherapy.

First Author, Year	N	Sites	Stage	% IMRT	% CCRT	MTV Delineation Method	Median MTV (cc)	MTV P value				SUVmax
								LRC	FDM	DFS	OS
Chung, 2009	82	NP, OP, HP	I, II, III, IV	Not stated	90%	Fixed SUV 2.5 threshold	39	0.03	–	0.04	–	Not Predictive
La, 2009	85	NP, OC, OP, HP, L, UP	II, III, IV	89%	100%	50% threshold	11.2	–	<0.001	–	<0.001	Not Predictive
Deron, 2011	22a	OC, OP, HP, L	III, IV	100%	100%	50% threshold	31.3	–	0.04	–	NS	Not Predictive
Romesser, 2012	41	NP, OC, OP, HP, L	I, II, III, IV	100%	89%	Gradient dependent	7.2	0.0003	0.002	0.001	0.04	Not Predictive
Lim, 2012	176	OP	I, II, III, IV	100%	100%	42% threshold	9.7	0.005	<0.001	–	<0.001	OS
Tang, 2012	83	NP, OC, OP, HP, L, UP	I, II, III, IVb	95%	96%	50% threshold	10.5	0.014	0.023	0.0002	0.005	Distant metastasis
Picchio, 2014	19	OP, NP, L	I, II, III, IV	100%	84%	40% threshold	21.1c	<0.01	<0.05	<0.025	<0.005	Not Predictive
Current study	100	OP	I, II, III, IV	100%	100%	42% threshold	9.7	0.049	0.005	0.015	0.008	Not Predictive

Abbreviations: CCRT, concurrent chemoradiation therapy; DFS, disease-free survival; FDM, freedom from distant metastasis; IMRT, intensity-modulated radiation therapy; LRC, locoregional control; OS, overall survival; SUV, standardized uptake value.

^aReference limited to analysis on 22 non-surgical patients.

^bDeduced from TNM data.

^cMean value.