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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2016 Jul 16;29:77–89. doi: 10.1016/j.coph.2016.07.005

Figure 2. Obesity and colorectal cancer.

Figure 2

Obesity is associated with changes in the intestinal microbiome and dysfunction of the intestinal barrier. Gut dysbiosis and endotoxemia promotes inflammation through the upregulation inflammatory cytokines, particularly IL-6, TNF-α, IL-17 and IL-23, which promote CRC carcinogenesis. Obesity-associated changes in leptin and adiponectin also leads to increased inflammation and CRC carcinogenesis.