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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Immunol. 2016 Aug 1;197(5):1832–1842. doi: 10.4049/jimmunol.1600143

Figure 4. Chronic SIV infection results in accumulation of IL-21+ and IFN-γ+ cells within the follicles.

Figure 4

(a) Representative IHC images showing IFN-γ+ and IL-21+ cells in the follicles, T cell zone, and medulla of LN of SIV-naïve and SIV+ RMs with low (<100 copies) and high (>10,000 copies) viral load. (b) Expression of IL-21 in follicles. (c) Expression of IFNγ in follicles. Each dot indicates the percentage of cytokine intensity in one follicle. (d) Correlation between the expression of IFN-γ+ and IL-21+ cells in follicles.