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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Immunol. 2016 Aug 1;197(5):1832–1842. doi: 10.4049/jimmunol.1600143

Figure 5. Both CXCR3+ and CXCR3− GC-Tfh cells help B cells equally irrespective of their functional difference.

Figure 5

Sorted CXCR3+ GC-Tfh and CXCR3− GC-Tfh cells from chronic SIV infected macaques were co-cultured with autologous sorted B cells. (a) Total numbers of viable B cells at day 5 from the T and B co-culture experiment. (b) IgG production by sorted B cells (B cell alone) from SIV infected RM in the presence of IFN-γ (5ng/ml) or IL-21 (10ng/ml). (c) IgG (n=4) and (d) IgG1 (n=3) concentrations at day 9 in T and B co-culture experiments. (e) Correlation between SIV-envelop specific IgG (at 1: 9000 dilution of sera) antibody levels and total, CXCR3+ or CXCR3− GC-Tfh cells at 24 weeks post SIV infection. (f) Correlation between SIV-envelop specific IgG1 (at 1: 450 dilution of sera) antibody levels and total, CXCR3+ or CXCR3− GC-Tfh cells at 24 weeks post SIV infection.