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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Exp Neurol. 2016 Jul 2;283(Pt A):308–317. doi: 10.1016/j.expneurol.2016.06.028

Figure 1. Adrenalectomy and corticosterone replacement.

Figure 1

(a) Timeline for experiment (b) HD mice on high/HD level replacement showed a progressive reduction in bodyweight starting at 8 weeks of age relative to sham HD mice (Tukey's post-hoc p<.05, indicated by #) and starting at week 10 relative to physiological/WT level replacement in adrenalectomized HD mice (Tukey's post-hoc, p<.05, indicated by *). (c) HD mice on high/HD level CORT replacement showed a significant reduction in survival relative to sham treated HD mice (p<.001) and HD mice on physiological/WT-level corticosterone replacement (p<.01). (d) Although R6/2 showed a reduction in distance traveled relative to WT mice, there was no effect of treatment on either R6/2 or WT mice (p>.05). (e) As expected, plasma CORT was higher in mice on the high/HD-level corticosterone replacement than the sham treated mice and physiological/WT-level corticosterone replacement groups. There was no difference in plasma corticosterone levels between R6/2 and WT mice in any of the treatment groups (p>.05).