Table II.

Characteristics of patients with paraneoplastic syndromes associated with MCC

PNS type	Sex	Age at MCC diagnosis	Stage at MCC diagnosis	Age at PNS diagnosis	Extent of disease at PNS diagnosis	Resolution of PNS?	Vital Stats (at end of study period)	Follow up time (Months)
Hyponatremia	M	52	IIA	53	Distant metastatic disease	Y- following palliative radiation therapy	Alive with disease	47
Hyponatremia	F	54	IV	55	Distant metastatic disease	N – disease progression resistant to multiple therapies	Died of disease	18
Hyponatremia	M	66	IIA	69	Distant metastatic disease	N –recurrent hyponatremia following palliative radiation therapy and progressive disease	Died of Disease	32
Hyponatremia	M	52	IIIB - UP**	54	Distant metastatic disease	N – disease progression resistant to chemotherapy	Alive with Disease	20
Hyponatremia	M	57	IIIB - UP**	56	Onset of PNS prompted scan, occult disease detected	Y – after lymph node dissection	Alive with no disease	62
* LEMS	M	59	IIIB – UP**	59	Onset of PNS prompted work up, occult disease detected after persistent symptoms and scans	Y – after lymph node dissection and RT to tumor	Alive with no disease	44
* LEMS	M	82	IIB	82	Presented with symptoms of PNS prior to detection of distant metastatic disease	N – disease progression resistant to chemotherapy	Died of Disease	9
Cerebellar Degeneration	M	63	IIIB – UP**	63	Onset of PNS prompted scan, occult disease detected	Y - Improvement of neurological symptoms after completion lymphadenectomy and radiation therapy	Alive with no disease	86

^*LEMS = Lambert-Eaton Myasthenic Syndrome

^**UP = Unknown primary