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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2016 Jul 17;29:90–96. doi: 10.1016/j.coph.2016.06.009

Figure 1. Intratumoral Hypoxia→HIF-1α driven and A2A/A2B Adenosine Receptor-mediated suppression of anti-tumor T cells.

Figure 1

Shown are the HIF-1α regulated ecto-enzymes CD39/CD73 which act in tandem to generate extracellular adenosine. Adenosine triggers the accumulation of immunosuppressive intracellular cAMP by signaling through high affinity A2AR and low affinity A2BR. HIF-1α is also shown to suppress cells of the adaptive immune system [20].

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