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The EGFR receptor family. (A) A schematic showing the structure of the four EGFR family receptors (EGFR, ErbB2, ErbB3, and ErbB4), including the four domains within the extracellular region, the intracellular tyrosine kinase domain and the ligands specific to each receptor. EGFR, ErbB3, and ErbB4 are shown in the unliganded, “closed” conformation. (B) The conformational change associated with ligand binding, receptor dimerisation and formation of an allosteric kinase domain dimer.
