Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Definition of the region of interest (ROI) for the locus coeruleus (LC) in the neuromelanin-MRI images involved identifying the highest intensity voxel adjacent to the fourth ventricle (LCMAX), which together with its four adjacent voxels were then used to calculate LC signal intensity. The circular reference ROI in the pontine tegmentum is also indicated.
