Table 1.
Brain imaging findings in patients with PD and healthy subjects.
| Patients with PD | Healthy controls | p-value | ||
|---|---|---|---|---|
| SPECT with FP-CIT | Putamencontra | 1.60 ± 0.67 | 4.60 ± 0.83 | P < 0.001 |
| Putamenipsi | 2.06 ± 0.75 | 4.65 ± 0.83 | P < 0.001 | |
| AIPutamen | 28.09 ± 22.08 | 2.39 ± 1.75 | P < 0.001 | |
| Caudatecontra | 2.97 ± 1.02 | 4.92 ± 0.98 | P < 0.001 | |
| Caudateipsi | 3.28 ± 0.97 | 4.94 ± 0.96 | P < 0.001 | |
| AICaudate | 20.84 ± 26.71 | 3.22 ± 2.33 | P < 0.001 | |
| NM-MRI | SN volume-contra | 236 ± 50 mm3 | 344 ± 51 mm3 | P < 0.001 |
| SN volume-ipsi | 283 ± 84 mm3 | 362 ± 60 mm3 | P < 0.01 | |
| AISN-volume | 21.88 ± 15.32 | 13.82 ± 8.22 | P > 0.05 | |
| CNRSN-contra | 4.28 ± 0.41 | 4.91 ± 0.38 | P < 0.001 | |
| CNRSN-ipsi | 4.42 ± 0.45 | 4.83 ± 0.37 | P < 0.01 | |
| AISN-CNR | 8.59 ± 7.25 | 6.08 ± 3.72 | P > 0.05 | |
| CNRLC-contra | 3.54 ± 0.87 | 4.89 ± 0.61 | P < 0.0001 | |
| CNRLC-ipsi | 3.85 ± 0.96 | 5.07 ± 0.47 | P < 0.001 | |
| Iron-sensitive MRI | R2*contra | 41.17 ± 10.96 s−1 | 37.47 ± 5.16 s−1 | P > 0.05 |
| R2*ipsi | 43.30 ± 10.01 s−1 | 39.09 ± 5.74 s−1 | P > 0.05 | |
| Susceptibilitycontra | 0.16 ± 0.05 ppm | 0.13 ± 0.03 ppm | P > 0.05 | |
| Susceptibilityipsi | 0.15 ± 0.05 ppm | 0.13 ± 0.03 ppm | P > 0.05 |
Data listed as mean ± standard deviation. PT, putamen; CN, caudate nucleus; AI, asymmetry index; Vol, volume; SN, substantia nigra; CNR, contrast-to-noise-ratio; contra, contralateral (to the side opposite to the clinically most impaired hemibody) and ipsi, ipsilateral. For HC we adopted the conventional of referring to the right side as ipsilateral.