Table 2.
Population PK parameters of artefenomel in the human malaria challenge model
| Parameter | Population estimate (SE; % coefficient of variation) | Inter-individual variabilitya (SE) |
|---|---|---|
| Vc/F (L) | 189 (61–32%) | 0.269 (0.271) |
| Vp/F (L) | 1573 (177–11%) | 0.071 (0.08) |
| CL/F (L/h) | 40.9 (3.8–9%) | 0.064 (0.04) |
| Q/F (L/h) | 12.7 (2.0–16%) | not estimated |
| Ka (h−1) | 0.18 (0.023–13%) | not estimated |
| ALAGb (h) | 0.40 (0.03–8%) | 0.001 (0.001) |
| Dose on CL/Fc | 0.55 (0.11–20%) | not estimated |
SE, standard error; Vc, Vp, volume of distribution in the central and peripheral compartments.
aVariance of inter-individual random effects ηi.
bLag phase.
cCL/Fdose = CL/F0 × (dose/500)−0.55, where CL/F0 is the typical value of clearance.