Table 2. Impact of baseline characteristics on patient prognosis according to adjuvant chemotherapy (N = 202).
| Doxorubicin N = 116 (%) | 5Y DRFS (%) | P-value | CMF1 N = 86 (%) | 5Y DRFS (%) | P-value | |
|---|---|---|---|---|---|---|
| Age (median) | 46.3 ± 9.7 | 0.534 | 46.4 ± 0.9 | 0.077 | ||
| Range | 28.3–74.1 | 23.5–73.1 | ||||
| <40 YO1 | 29 (25.0) | 82.6 | 19 (22.1) | 78.9 | ||
| ≥40 YO | 87 (75.0) | 80.4 | 67 (77.9) | 94.0 | ||
| Histology | 0.765 | 0.207 | ||||
| IDC2 | 108 (93.1) | 71 (82.6) | 91.5 | |||
| Other | 8 (6.9) | 15 (17.4) | 86.7 | |||
| Stage | <0.001 | 0.860 | ||||
| I | 21 (18.1) | 90.5 | 34 (39.5) | 91.2 | ||
| IIA | 48 (41.4) | 93.8 | 46 (53.5) | 89.1 | ||
| IIB | 26 (22.4) | 73.1 | 6 (7.0) | 100.0 | ||
| IIIA | 13 (11.2) | 67.7 | 0 (0) | NA | ||
| IIIB | 0 (0) | NA | 0 (0) | NA | ||
| IIIC | 8 (6.9) | 25.0 | 0 (0) | NA | ||
| Nuclear grade | 0.503 | 0.134 | ||||
| 1 | 0 (0) | NA | 2 (2.3) | 50.0 | ||
| 2 | 31 (26.7) | 80.3 | 16 (18.6) | 87.5 | ||
| 3 | 83 (71.6) | 81.9 | 61(71.0) | 93.4 | ||
| Unknown | 2 (1.7) | 50.0 | 7 (8.1) | 85.7 | ||
| Histologic grade | 0.898 | 0.395 | ||||
| 1 | 1 (0.9) | 100.0 | 2 (2.3) | 100.0 | ||
| 2 | 25 (21.5) | 84.0 | 20 (23.3) | 85.0 | ||
| 3 | 87 (75.0) | 79.1 | 56 (65.1) | 94.6 | ||
| Unknown | 3 (2.6) | 66.7 | 8 (9.3) | 75.0 | ||
| Adjuvant RTx3 | 0.052 | 0.814 | ||||
| Yes | 79 (68.1) | 77.1 | 51 (59.3) | 92.2 | ||
| No | 37 (31.9) | 89.2 | 35 (40.7) | 88.6 | ||
| NFKB1 (median: 25.60) | 0.034 | 0.948 | ||||
| Low | 62 (53.4) | 74.2 | 39 (45.3) | 92.3 | ||
| High | 54 (46.6) | 88.8 | 47 (54.7) | 89.4 | ||
| NFKB2 (median: 297.30) | 0.754 | 0.864 | ||||
| Low | 55 (47.4) | 81.7 | 46 (53.5) | 89.1 | ||
| High | 61 (52.6) | 80.3 | 40 (46.5) | 92.5 | ||
| RELA (median: 224.85) | 0.023 | 0.832 | ||||
| Low | 55 (47.4) | 90.8 | 45 (52.3) | 88.9 | ||
| High | 61 (52.6) | 72.1 | 41 (47.7) | 92.7 | ||
| RELB (median: 61.25) | 0.666 | 0.715 | ||||
| Low | 57 (49.1) | 82.3 | 44 (51.7) | 90.9 | ||
| High | 59 (50.9) | 79.6 | 42 (48.8) | 90.5 | ||
| REL (median: 65.48) | 0.460 | 0.716 | ||||
| Low | 67 (57.8) | 77.6 | 34 (39.5) | 91.2 | ||
| High | 49 (42.2) | 85.6 | 52 (60.5) | 90.4 | ||
| TP53 (median: 221.06) | 0.886 | 0.750 | ||||
| Low | 59 (50.9) | 79.7 | 42 (48.8) | 92.9 | ||
| High | 57 (49.1) | 82.3 | 44 (51.2) | 88.6 | ||
| FOXC1 (median: 126.94) | 0.208 | 0.279 | ||||
| Low | 59 (50.9) | 86.3 | 42 (48.8) | 88.1 | ||
| High | 57 (49.1) | 75.4 | 44 (51.2) | 93.2 | ||
| TBP (median: 92.68) | 0.609 | 0.158 | ||||
| Low | 61 (52.6) | 81.8 | 39 (45.3) | 94.9 | ||
| High | 55 (47.4) | 80.0 | 47 (54.7) | 87.2 | ||
| SP1 (median: 100.01) | 0.001 | 0.193 | ||||
| Low | 52 (44.8) | 92.3 | 49 (57.0) | 87.8 | ||
| High | 64 (55.2) | 71.6 | 37 (43.0) | 94.6 | ||
| STAT3 (median:1599.68) | 0.122 | 0.082 | ||||
| Low | 58 (50.0) | 86.1 | 43 (50.0) | 86.0 | ||
| High | 58 (50.0) | 75.9 | 43 (50.0) | 95.3 | ||
| IRF1 (median: 192.75) | 0.695 | 0.599 | ||||
| Low | 51 (44.0) | 82.2 | 50 (58.1) | 90.0 | ||
| High | 65 (56.0) | 80.0 | 36 (41.9) | 91.7 |
1Years old, 2Invasive ductal carcinoma, 3Radiotherapy.