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. 2015 Nov 30;1:15051. doi: 10.1038/cddiscovery.2015.51

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Copyright © 2015 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The effect of FVII on PAR2, p-ERK1/2 and CD34 levels in mouse xenograft model. Subcutaneously grown HepG2 tumors were injected into NOD/SCID mice. TF, FVIIa or PAR2 agonist was directly injected into the grafted tumors. (a) The expression levels of the three coagulation factors and p-ERK1/2 in tumor tissue were determined by western blot analyses. (b) Immunohistochemistry for PAR2, p-ERK1/2 and CD34 in tumor tissue treated with TF, FVIIa and PAR2 were also determined. Representative results from five independent animal experiments are shown. FVII significantly increased levels of PAR2, p-ERK1/2 and the microvessel density (MVD) in HepG2 xenograft.