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Combination of rapamycin and bafilomycin treatment suggest a new mechanism for clearing intramyocellular lipids. L6 myocytes were treated with rapamycin, bafilomycin, and a combination of both rapamycin and bafilomycin. (a) LC3-II, (b) p62, and (c) cleaved caspase-3 protein levels. Data are expressed in fold change of protein levels versus BSA control at 0.0 mM oleate/palmitate (*P<0.05; **P<0.01; ***P<0.001; NS, not significant).
