TABLE 1. Key Attributes of Diagnostic Tests.

Test availability

•Cost or reimbursement •Storage, technical feasibility (e.g., climate control, shelf life, electricity, bench space) •Knowledge/expertise required to perform and interpret test •Time taken to conduct test •Need for and supply of reagents/supplies •Maintenance, calibration, quality control

Test experience

•Preparation required (e.g., fasting, bowel preparation •Speed of getting results •Physical effects of the test (e.g., pain, bleeding) •Psychological effects of the test itself (e.g., anxiety, improved knowledge, change in behavior

Test results

•Accuracy (e.g., sensitivity, specificity) •Precision/Reproducibility •Ability to act on result (e.g., whether the test result allows a clinical decision to be made). •Diagnostic confidence (e.g., the impact of a test on patient or clinician’s willingness to take action) •Interpretability (e.g., understanding the meaning of the test)