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. 2016 Aug 17;11:3951–3967. doi: 10.2147/IJN.S107952

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© 2016 Zang et al. This work is published and licensed by Dove Medical Press Limited

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Physicochemical characteristics of complexes.

Notes: The particle sizes (columns) and zeta potentials (lines) of EPSLR at different N/P ratios (A) and its reference formulations at an N/P ratio of 9 (B). Morphology of Eph-modified liposomes was characterized with TEM after staining with phosphotungstic acid (C).

Abbreviations: LR, liposome–siRNA complexes; siRNA, small interfering RNA; PSLR, PEGylated LR; EPSLR, PSLR-conjugated anti-EphA10 antibody; TEM, transmission electron microscopy; N/P ratios, molar ratio of DOTAP-nitrogen atoms to siRNA-phosphate; Eph, anti-EphA10 antibody.