Table 2. Factors associated with the occurrence of the first non-AIDS events.

Final multivariate model without any measure of immune restoration. APPROCO/ COPILOTE (ANRS CO8) cohort study 1997–2009.

Factor studied	Non-AIDS events n (%)	Crude HR	p	Adjusted HR	95%CI	p
Age at baseline (years)			0.02			<0.001
<30	71 (38.0)	1		1
[30–40]	247 (40.4)	0.95		0.85	0.64–1.12
[40–50]	136 (48.6)	1.13		1.10	0.82–1.48
[50–60]	53 (51.5)	1.25		1.34	0.93–1.93
≥ 60	29 (63.0)	1.75		1.93	1.25–3.01
Gender			0.63
Male	415 (43.8)	1
Female	121 (43.2)	1.05
Presumed route of HIV transmission			< 0.001
Sex between men	189 (38.4)	1
Sex between men and women	175 (42.9)	1.19
Intravenous drug use	105 (53.6)	1.77
Haemophilia	9 (69.2)	2.37
Others/unknown	40 (42.1)	1.19
CDC stage C at baseline			0.03			0.025
No	411 (42.0)	1		1
Yes	125 (50.4)	1.24		1.26	1.02–1.55
Tobacco smoking at baseline			0.02
Yes or unknown	357 (45.0)	1
No	179 (41.3)	0.81
Alcohol consumption at baseline			0.04
Yes or unknown	437 (42.9)	1
No	99 (47.6)	1.25
HBV infection			0.04			0.021
No	504 (43.2)	1		1
Yes	32 (54.2)	1.46		1.49	1.04–2.14
HCV infection			< 0.001			<0.001
No	381 (40.1)	1		1
Yes	155 (56.2)	1.64		1.76	1.45–2.15
Time-dependent plasma HIV RNA (copies/mL)			0.001			<0.001
≥ 500	-	1		1
< 500		0.73		0.70	0.58–0.85

Abbreviations: HR: hazard ratio; CI: confidence interval.