Table 3. Comparison of four measures of immune restoration in prediction of occurrence of first non AIDS-defining severe events.

ANRS CO8 (APROCO/COPILOTE) 1997–2009.

Model 1 AIC = 6772.54
Time-dependent variable	Adjusted* HR	95% CI	p
CD4+ cell count (/mm3)
<100	1
100–200	0.39	0.25–0.60	<0.001
200–500	0.43	0.30–0.61	<0.001
≥ 500	0.31	0.21–0.46	<0.001
Model 2 AIC = 6796.47
Time-dependent variable	Adjusted* HR	95% CI	p
CD4/CD8 ratio
<0.5	1
0.5–1	0.86	0.71–1.05	0.16
≥ 1	0.71	0.53–0.96	0.03
Model 3 AIC = 6787.38
Time-dependent variable	Adjusted* HR	95% CI	p
Immune restoration variable
CD4 ≥ 500/mm3, CD4/CD8 ≤ 1	1
CD4 ≥ 500/mm3, CD4/CD8 > 1	0.88	0.62–1.23	0.46
CD4 < 500/mm3	1.39	1.13–1.70	0.001
Model 4 AIC = 6772.36
Time-dependent variable	Adjusted* HR	95% CI	p
CD4+ cell count (/mm3)
<100	1
100–200	0.39	0.25–0.60	<0.001
200–500	0.43	0.30–0.61	<0.001
≥ 500	0.31	0.21–0.46	<0.001
CD4/CD8 ratio
<0.5	1
0.5–1	1.02	0.82–1.26	0.85
≥ 1	0.88	0.64–1.22	0.46

Abbreviations: AIC: Akaike Information Criterion. HR: hazard ratio; CI: confidence interval.

* Adjusted on age, stage AIDS, plasma HIV RNA level, HCV and HBV infections.