. 2016 Aug 22;11(8):e0161594. doi: 10.1371/journal.pone.0161594

Table 4. Comparison of four measures of immune restoration in prediction of occurrence of first non AIDS-defining cancer.

ANRS CO8 (APROCO/COPILOTE) 1997–2009.

*Model 1 AIC = 936.79*
Time-dependent variable	Adjusted^* HR	95% CI	p
CD4+ cell count (/mm³)
<100	1
100–200	0.22	0.05–0.92	0.04
200–500	0.35	0.13–0.92	0.03
≥ 500	0.22	0.08–0.59	0.002
*Model 2 AIC = 932.16*
Time-dependent variable	Adjusted^* HR	95% CI	p
CD4/CD8 ratio
<0.5	2.13	1.32–3.45	0.002
≥0.5	1
*Model 3 AIC = 938.41*
Time-dependent variable	Adjusted^* HR	95% CI	p
Immune restoration variable
CD4 ≥ 500/mm³, CD4/CD8 ≤ 1	1
CD4 ≥ 500/mm³, CD4/CD8 > 1	0.64	0.62–1.23	0.34
CD4 < 500/mm³	1.47	0.87–2.47	0.14
*Model 4 AIC = 933.40*
Time-dependent variable	Adjusted^* HR	95% CI	p
CD4+ cell count (/mm³)
<100	1
100–200	0.23	0.05–0.96	0.04
200–500	0.43	0.16–1.14	0.09
≥ 500	0.35	0.12–1.00	0.05
CD4/CD8 ratio
<0.5	1
≥0.5	0.53	0.31–0.90	0.02

Abbreviations: AIC: Akaike Information Criterion. HR: hazard ratio; CI: confidence interval.

* Adjusted on age and HCV infection.