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. 2016 Aug 22;11(8):e0160786. doi: 10.1371/journal.pone.0160786

Fig 6. ION ligation induces synaptic plasticity in the S1BF, motor and cingulate cortices.

Fig 6

A-B: Representative examples of Piccolo staining (arrow heads) in the deep laminae of the S1BF cortex in sham (A) and ION (B) mice 5 weeks after surgery. Scale bar = 50μm. C-D: Representative examples of p-Cofilin staining (arrow heads) in the deep laminae of the S1BF cortex in sham (C) and ION (D) mice. Scale bar = 50μm. E: Double immunostaining showing NeuN (green)/p-Cofilin (red) positive neurons in the S1BF (arrows). The arrow head point at a NeuN positive neuron negative for pcofilin. Scale bar = 25μm. F: Quantification of Piccolo staining in the S1BF, motor and cingulate cortices in deep and superficial laminae. ION ligation induced the upregulation of Piccolo staining in deep laminae in the S1BF and the motor cortex. Data are expressed as means ± SEM. *p<0.05 and **p<0.01 ***p<0.001 vs. sham mice, (n = 5 sham, n = 5 ION).