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Structures of Ago2-siRNA complexes. (a) unmodified-siRNA, and (b) modified-siRNA guides bound to Ago2. 2Fo-Fc electron density maps surrounding the siRNAs are displayed as wire mesh. (c) Superposition of Ago2 Cα backbones from unmodified and modified structures. Unmodified siRNA in red. (d) Superposition of unmodified and modified siRNAs. Nucleotides numbered from 5′ ends.
