Table 4.
Least square means ± standard error of histological scores in ESL-M, ESL-L and ED samples compared at 12 and at 24 months.
| Categories | Months after surgery | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| 12 | 24 | |||||||
|
| ||||||||
| Treatments | Treatments | |||||||
|
| ||||||||
| ESMa | ESLb | EDc | P value | ESM | ESL | ED | P value | |
| total histological score | 46.4±2.3 | 48.9±2.3d | 40.8±2.3e | d,e:<0.05 | 48.7±2.5d | 44.5±2.5 | 40.7±2.5e | d,e:<0.05 |
| filling of defect | 2.0±0.2 | 2.0±0.2 | 1.8±0.2 | 1.7±0.2 | 1.7±0.2 | 1.5±0.2 | ||
| cartilage | 9.6±0.7 | 9.2±0.7 | 8.6±0.7 | 9.5±0.8 | 8.5±0.8 | 7.7±0.8 | ||
| matrix | 8.0±0.7 | 8.6±0.7 | 7.2±0.7 | 9.0±0.8 | 9.0±0.8 | 6.7±0.8 | ||
| bone | 7.0±0.4d | 7.6±0.4e | 6.4±0.4f |
d,e:<0.05 e,f:<0.01 |
7.5±0.4 | 7.5±0.4 | 7.2±0.4 | |
| edges | 2.8±0.4 | 2.6±0.4 | 1.8±0.4 | 3.2±0.5d | 2.0±0.5e | 1.5±0.5f |
d,e:<0.05 d,f:<0.01 |
|
| degeneration | 11.2±0.4 | 11.0±0.4 | 10.2±0.4 | 10.7±0.5 | 10.0±0.5 | 10.0±0.5 | ||
| vascularity | 5.8±1.0d | 8.0±1.0 | 4.6±1.0e | d,e:<0.01 | 7.0±1.1 | 5.7±1.1 | 5.7±1.1 | 6.0±1.1 |
a
Embryonic stem-like cells engrafted in the medial femoral condyle;
b
embryonic stem-like cells engrafted in the lateral femoral condyle;
c
Empty defect