Table 4.
No. of Patients (%) | ||||||||
CML in Myeloid Blast Phase | CML in Lymphoid Blast Phase | |||||||
Dasatinib 140 mg | Dasatinib 70 mg BID | Dasatinib 140 mg | Dasatinib 70 mg BID | |||||
Adverse Events Nonhematologic |
All Grades |
Grade 3/4 |
All Grades |
Grade 3/4 |
All Grades |
Grade 3/4 |
All Grades |
Grade 3/4 |
No. of patients | 74 | 74 | 33 | 28 | ||||
Fluid retention | 25 (34) | 4 (5) | 23 (31) | 8 (11) | 7 (21) | 2 (6) | 11 (39) | 2 (7) |
Pleural effusion | 15 (20) | 4 (5) | 13 (18) | 4 (5) | 7 (21) | 2 (6) | 10 (36) | 1 (4) |
Superficial edema | 10 (14) | 0 (0) | 10 (14) | 2 (3) | 1 (3) | 0 (0) | 7 (25) | 0 (0) |
Other | 7 (9) | 1 (1) | 7 (9) | 4 (5) | 0 (0) | 0 (0) | 3 (11) | 1 (4) |
Diarrhea | 15 (20) | 4 (5) | 15 (20) | 2 (3) | 6 (18) | 0 (0) | 11 (39) | 2 (7) |
Headache | 13 (18) | 1 (1) | 9 (12) | 1 (1) | 5 (15) | 1 (3) | 7 (25) | 2 (7) |
Bleeding | 14 (19) | 7 (9) | 20 (27) | 7 (9) | 8 (24) | 3 (9) | 6 (21) | 1 (4) |
Other | 9 (12) | 2 (3) | 10 (14) | 1 (1) | 4 (12) | 1 (3) | 4 (14) | 0 (0) |
GI bleeding | 7 (9) | 5 (7) | 11 (15) | 6 (8) | 3 (9) | 1 (3) | 1 (4) | 0 (0) |
CNS bleeding | 0 (0) | 0 (0) | 2 (3) | 0 (0) | 1 (3) | 1 (3) | 1 (4) | 1 (4) |
Nausea | 17 (23) | 1 (1) | 9 (12) | 0 (0) | 7 (21) | 1 (3) | 7 (25) | 1 (4) |
Fatigue | 15 (20) | 1 (1) | 8 (11) | 0 (0) | 3 (9) | 1 (3) | 4 (14) | 2 (7) |
Rash | 11 (15) | 1 (1) | 9 (12) | 0 (0) | 7 (21) | 0 (0) | 3 (11) | 0 (0) |
Febrile neutropenia | 9 (12) | 9 (12) | 5 (7) | 5 (7) | 4 (12) | 4 (12) | 3 (11) | 3 (11) |
No. of Patients (%) | ||||||||
CML in Myeloid Blast Phase | CML in Lymphoid Blast Phase | |||||||
Dasatinib 140 mg | Dasatinib 70 mg BID | Dasatinib 140 mg | Dasatinib 70 mg BID | |||||
Cytopenias | All Grades |
Grade 3/4 |
All Grades |
Grade 3/4 |
All Grades |
Grade 3/4 |
All Grades |
Grade 3/4 |
No. of patients | 72 | 73 | 33 | 28 | ||||
Neutropenia | 65 (90) | 57 (79) | 65 (89) | 54 (74) | 31 (94) | 26 (79) | 26 (93) | 24 (86) |
Thrombocytopenia | 67 (93) | 58 (81) | 67 (92) | 58 (80) | 32 (97) | 28 (85) | 28 (100) | 24 (86) |
Anemia | 70 (97) | 55 (76) | 73 (100) | 57 (78) | 33 (100) | 17 (52) | 28 (100) | 14 (50) |
Leukocytopenia | 60 (83) | 44 (61) | 61 (84) | 44 (60) | 30 (91) | 26 (79) | 26 (93) | 18 (64) |
CML indicates chronic myeloid leukemia; QD, once daily; BID, twice daily; GI, gastrointestinal; CNS, central nervous system.