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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Mol Psychiatry. 2016 Mar 15;21(9):1232–1243. doi: 10.1038/mp.2016.15

Figure 1. Expression of the human DISC1 protein in larval MB neurons.

Figure 1

A. Full-length DISC1 (magenta) was expressed using a MB-GAL4 driver, 201Y, which drives gene expression in MB neurons. Cells were labeled with a membrane-bound marker, UAS-mCD8::GFP (green). Third instar larval stage. Kc (Kenyon cells): the cell bodies of MB neurons. Cx (calyx): the dendritic structure. Lb (lobe): the axonal extensions. Scale bar, 50 μm.

B. Subcellular localization patterns of DISC1 in larval MB neurons. The DISC1 protein FL (1-854) exhibited punctate dots in many of the nuclei. DISC1 also showed diffuse pattern in the nucleus and the perinuclear cytoplasm. Magenta, DISC1. Green, mCD8::GFP. Scale bar, 10 μm.

C. DISC protein domains and the deletion/mutant constructs. NLS, nuclear localization signal; SF, Ser-Phe rich domain; NES, nuclear exclusion signal; LZ, leucine-zipper domain. Representative interacting proteins and DISC1 genetic variants associated with mental disorders1–4 are shown above the structure. Q264R, L607F and S704C are common variants associated with schizophrenia. L607F and S704C are also associated with schizoaffective disorder (SAD) and major depression (MD). G14A, R37W, S90L and T603I are rare variants associated with schizophrenia (SZ). S209R, R338Q and T754S are rare variants associated with bipolar disorder (BP).