Skip to main content
. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Mol Psychiatry. 2016 Mar 15;21(9):1232–1243. doi: 10.1038/mp.2016.15

Figure 5. Overexpression of DISC1 suppresses synaptic development in larval NMJ.

Figure 5

A. Branching patterns of wild-type and DISC1 overexpression (DISC1OE) NMJs. Green, motor neuron termini labeled with an anti-neuronal antibody (anti-HRP). Magenta, synaptic boutons labeled with anti-Synaptotagmin (SYT). Muscle 6/7 of the second abdominal segment in late third instar larvae (116–120 hours after egg collection). UAS-DISC1 was driven with a ubiquitous driver, tubP-GAL4. Scale bar, 40 μm.

B–D. Quantification of NMJ synaptogenesis in DISC1 overexpression NMJ. B. Total synaptic bouton area. C. Number of synaptic boutons. D. Number of axonal branching points. *p < 0.05 and **p < 0.01 with one-way ANOVA and Dunnett’s post hoc test, n = 10 ~26.