Table 2.

Risk factors for moderate to severe hot flashes during 14 years of follow–up (N=233)

Variable	Unadjusted			Adjusted
				Model with Somatic Anxiety			Model with Affective Anxiety
	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value
Anxiety (Zung)
Total (mean)	1.02	1.01–1.04	0.005
Somatic dimension (mean)	1.91	1.36–2.67	<0.001	3.13	2.16–4.53	<0.001
Affective dimension (mean)	1.03	0.82–1.30	0.780				1.19	0.96–1.48	0.117
Menopausal stage			<0.001			<0.001			<0.001
Premenopausal	Reference	–––	––	Reference	–––	–––	Reference	___	___
Early transition	2.54	1.82–3.54	<0.001	1.89	1.32–2.73	< 0.001	1.75	1.22–2.50	0.002
Late transition	6.40	4.45–9.20	<0.001	2.77	1.75–4.40	<0.001	3.31	2.12–5.17	<0.001
Early postmeno	7.22	4.94–10.55	<0.001	3.89	2.24–6.75	<0.001	3.42	1.98–5.91	<0.001
Late postmeno	5.23	3.24–8.44	<0.001	2.21	1.04–4.70	0.040	1.95	0.92–4.10	0.080
Age, current (y)	1.11	1.09–1.14	<0.001	1.10	1.05–1.15	<0.001	1.09	1.04–1.14	<0.001
History of depression³	1.62	1.14–2.29	0.007	1.36	0.90–2.05	0.145	1.60	1.06–2.42	0.023
log Estradiol, pg/mL¹,²,³	0.84	0.80–0.90	<0.001	0.96	0.90–1.03	0.236	0.96	0.90–1.02	0.162
log FSH, mIU/mL¹,²,³	1.21	1.16–1.26	<0.001	1.06	1.00–1.13	0.059	1.05	0.99–1.12	0.126
Education³
>HS	0.65	0.46–0.92	0.015	0.68	0.46–1.01	0.056	0.64	0.43–0.96	0.029
≤HS	Reference	–––	–––	Reference	–––	–––	Reference	–––	–––
Current psychotropic medications	2.82	1.97–4.04	<0.001	0.41	1.29–2.95	0.002	2.02	1.34–3.07	<0.001
BMI ≥ 30	1.51	1.15–1.98	0.003
Race
African American	1.38	0.98–1.94	0.069
White	Reference	–––	––
Alcohol < 1/wk	0.76	0.56–1.03	0.076
Perceived stress (PSS)	1.01	0.99–1.02	0.236
Employed vs not employed	0.76	0.47–1.23	0.267
Current smoker	0.97	0.69–1.38	0.885

. OR is for mean log hormone per 1 SD.

. Hormones were added separately to the models.

. Variables at P>0.05 were retained in the models for consistency between the 2 models.